Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms

CYP2D enzymes engage in the synthesis of endogenous neuroactive substances (dopamine, serotonin) and in the metabolism of neurosteroids. The present work investigates the effect of iloperidone on CYP2D enzyme expression and activity in rat brains and livers. Iloperidone exerted a weak direct inhibit...

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Detalles Bibliográficos
Autores principales: Danek, Przemysław J., Daniel, Władysława A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700221/
https://www.ncbi.nlm.nih.gov/pubmed/34943983
http://dx.doi.org/10.3390/cells10123472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700221/
https://www.ncbi.nlm.nih.gov/pubmed/34943983
http://dx.doi.org/10.3390/cells10123472

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