The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene

Phosphatase and tensin homolog deleted on chromosome 10, or PTEN, is a well-characterized tumor suppressor with both lipid and protein phosphatase activities. PTEN is often downregulated by epigenetic mechanisms such as hypermethylation, which leads to constitutive activation of the PI3K–Akt pathway...

Descripción completa

Detalles Bibliográficos
Autores principales: Garrido, Jose Antonio Ma. G., Alcantara, Krizelle Mae M., Danac, Joshua Miguel C., Serrano, Fidel Emmanuel C., Cutiongco-de la Paz, Eva Maria, Garcia, Reynaldo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700245/
https://www.ncbi.nlm.nih.gov/pubmed/34943931
http://dx.doi.org/10.3390/cells10123423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700245/
https://www.ncbi.nlm.nih.gov/pubmed/34943931
http://dx.doi.org/10.3390/cells10123423

Ejemplares similares