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The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene

Phosphatase and tensin homolog deleted on chromosome 10, or PTEN, is a well-characterized tumor suppressor with both lipid and protein phosphatase activities. PTEN is often downregulated by epigenetic mechanisms such as hypermethylation, which leads to constitutive activation of the PI3K–Akt pathway...

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Detalles Bibliográficos
Autores principales:	Garrido, Jose Antonio Ma. G., Alcantara, Krizelle Mae M., Danac, Joshua Miguel C., Serrano, Fidel Emmanuel C., Cutiongco-de la Paz, Eva Maria, Garcia, Reynaldo L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700245/ https://www.ncbi.nlm.nih.gov/pubmed/34943931 http://dx.doi.org/10.3390/cells10123423

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