Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

Central tolerance is achieved through positive and negative selection of thymocytes mediated by T cell receptor (TCR) signaling strength. Thus, dysregulation of the thymic selection process often leads to autoimmunity. Here, we show that Capicua (CIC), a transcriptional repressor that suppresses aut...

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Detalles Bibliográficos
Autores principales: Kim, Soeun, Park, Guk-Yeol, Park, Jong Seok, Park, Jiho, Hong, Hyebeen, Lee, Yoontae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700290/
https://www.ncbi.nlm.nih.gov/pubmed/34895467
http://dx.doi.org/10.7554/eLife.71769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700290/
https://www.ncbi.nlm.nih.gov/pubmed/34895467
http://dx.doi.org/10.7554/eLife.71769

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