PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

Background: PXR is a xenobiotic-responsive nuclear receptor that controls the expression of drug-metabolizing enzymes. Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs. Our group recently reported a possible drug–drug inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Shizu, Ryota, Ezaki, Kanako, Sato, Takumi, Sugawara, Ayaka, Hosaka, Takuomi, Sasaki, Takamitsu, Yoshinari, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700377/
https://www.ncbi.nlm.nih.gov/pubmed/34944058
http://dx.doi.org/10.3390/cells10123550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700377/
https://www.ncbi.nlm.nih.gov/pubmed/34944058
http://dx.doi.org/10.3390/cells10123550

Ejemplares similares