NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice

Niemann–Pick C1-like 1 (NPC1L1) mediates intestinal uptake of dietary and biliary cholesterol and is the target of ezetimibe, a cholesterol absorption inhibitor used to treat hypercholesterolemia. Genetic deletion of NPC1L1 or ezetimibe treatment protects mice from high-fat diet (HFD)-induced obesit...

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Detalles Bibliográficos
Autores principales: Jia, Lin, Ma, Yinyan, Haywood, Jamie, Jiang, Long, Xue, Bingzhong, Shi, Hang, Dawson, Paul A., Yu, Liqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700447/
https://www.ncbi.nlm.nih.gov/pubmed/34943976
http://dx.doi.org/10.3390/cells10123468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700447/
https://www.ncbi.nlm.nih.gov/pubmed/34943976
http://dx.doi.org/10.3390/cells10123468

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