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NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice

Niemann–Pick C1-like 1 (NPC1L1) mediates intestinal uptake of dietary and biliary cholesterol and is the target of ezetimibe, a cholesterol absorption inhibitor used to treat hypercholesterolemia. Genetic deletion of NPC1L1 or ezetimibe treatment protects mice from high-fat diet (HFD)-induced obesit...

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Detalles Bibliográficos
Autores principales:	Jia, Lin, Ma, Yinyan, Haywood, Jamie, Jiang, Long, Xue, Bingzhong, Shi, Hang, Dawson, Paul A., Yu, Liqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700447/ https://www.ncbi.nlm.nih.gov/pubmed/34943976 http://dx.doi.org/10.3390/cells10123468

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