SARS-CoV-2 Ion Channel ORF3a Enables TMEM16F-Dependent Phosphatidylserine Externalization to Augment Procoagulant Activity of the Tenase and Prothrombinase Complexes

Severe SARS-CoV-2 infection is complicated by dysregulation of the blood coagulation system and high rates of thrombosis, but virus-intrinsic mechanisms underlying this phenomenon are poorly understood. Increased intracellular calcium concentrations promote externalization of phosphatidylserine (PS)...

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Detalles Bibliográficos
Autores principales: Ludington, Jacob G, Ansari, Shabbir A, Schmaier, Alec A, Enjyoji, Keiichi, Nilsson-Payant, Benjamin E, Bram, Yaron, Chandar, Vasuretha, Borczuk, Alain, tenOever, Benjamin R, Schwartz, Robert E, Schulman, Sol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology. Published by Elsevier Inc. 2021
Materias:
Plenary Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701469/
https://www.ncbi.nlm.nih.gov/pubmed/34236425
http://dx.doi.org/10.1182/blood-2021-150768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701469/
https://www.ncbi.nlm.nih.gov/pubmed/34236425
http://dx.doi.org/10.1182/blood-2021-150768

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