Cargando…

Investigation of Isocitrate Dehydrogenase 1 and 2 Mutations in Acute Leukemia Patients in Saudi Arabia

Different forms of human cancer show mutations for isocitrate dehydrogenases 1 and 2 (IDH1/2). Mutation of these genes can cause aberrant methylation of the genome CpG islands (CGIs), which leads to an increase of suppressed oncogenes transcription or repression of active tumor suppressor gene trans...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alkhatabi, Heba, Bin Saddeq, Haneen Abdulfattah, Alyamani, Luay, Shinawi, Thoraia, Yasin, Elrashed B., Alserihi, Raed, Felimban, Raed, Tayeb, Hossam H., Mimani, Rawan, Alalla, Zainab, Abu-Elmagd, Muhammad, Abuzenadah, Adel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701864/ https://www.ncbi.nlm.nih.gov/pubmed/34946913 http://dx.doi.org/10.3390/genes12121963

Ejemplares similares

TP53 Expression and Mutational Analysis in Hematological Malignancy in Jeddah, Saudi Arabia
por: Alkhatabi, Heba, et al.
Publicado: (2022)

Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks
por: Tayeb, Hossam H., et al.
Publicado: (2021)

Development of nanoemulsions for the delivery of hydrophobic and hydrophilic compounds against carbapenem-resistant Klebsiella pneumoniae
por: Tayeb, Hossam H., et al.
Publicado: (2022)

The association between different blood group systems and susceptibility to COVID-19: a single center cross-sectional study from Saudi Arabia
por: Hakami, Nora Y, et al.
Publicado: (2022)

Prenatal Exposure to Gabapentin Alters the Development of Ventral Midbrain Dopaminergic Neurons
por: Alsanie, Walaa F., et al.
Publicado: (2022)

Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system
por: Alhattab, Dana M., et al.
Publicado: (2023)

Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
por: Al Awaji, Nisreen Naser, et al.
Publicado: (2021)

The Influence of Prenatal Exposure to Quetiapine Fumarate on the Development of Dopaminergic Neurons in the Ventral Midbrain of Mouse Embryos
por: Alsanie, Walaa F., et al.
Publicado: (2022)

Genotype-protein phenotype characterization of NOD2 and IL23R missense variants associated with inflammatory bowel disease: A paradigm from molecular modelling, dynamics, and docking simulations
por: Nasser, Khalidah Khalid, et al.
Publicado: (2023)

Synthesis, Characterization and In Vitro Evaluation of Chitosan Nanoparticles Physically Admixed with Lactose Microspheres for Pulmonary Delivery of Montelukast
por: Ullah, Faqir, et al.
Publicado: (2022)

Identification of novel genetic variations affecting osteoarthritis patients
por: Gari, Mamdooh Abdullah, et al.
Publicado: (2016)

Distribution of Kell antigens K, k, Kp(a), and Kp(b) among blood donors in Jeddah city of Western Saudi Arabia
por: Felimban, Raed I., et al.
Publicado: (2021)

Enhancing the Antipsychotic Effect of Risperidone by Increasing Its Binding Affinity to Serotonin Receptor via Picric Acid: A Molecular Dynamics Simulation
por: Alhomrani, Majid, et al.
Publicado: (2022)

Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models
por: Schulten, Hans-Juergen, et al.
Publicado: (2022)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
por: Su, Li, et al.
Publicado: (2020)

Increasing the Efficacy of Seproxetine as an Antidepressant Using Charge–Transfer Complexes
por: Alsanie, Walaa F., et al.
Publicado: (2022)

Multispectral and Molecular Docking Studies Reveal Potential Effectiveness of Antidepressant Fluoxetine by Forming π-Acceptor Complexes
por: Gaber, Ahmed, et al.
Publicado: (2022)

Attempting to Increase the Effectiveness of the Antidepressant Trazodone Hydrochloride Drug Using π-Acceptors
por: Alsanie, Walaa F., et al.
Publicado: (2022)

The Quality of Blood Donation Services and Its Association with Blood Donors’ Trust and Loyalty at Makkah Blood Donation Centers in Saudi Arabia: A Cross-Sectional Study
por: Kabrah, Saeed M., et al.
Publicado: (2023)

Isocitrate dehydrogenase mutations in myeloid malignancies
por: Medeiros, B C, et al.
Publicado: (2017)

Prototype Development of an Expert System of Computerized Clinical Guidelines for COVID-19 Diagnosis and Management in Saudi Arabia
por: Banjar, Haneen Reda, et al.
Publicado: (2020)

Pairing 3D-Printing with Nanotechnology to Manage Metabolic Syndrome
por: El-Say, Khalid M, et al.
Publicado: (2022)

Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective
por: Ebada, Mahmoud A., et al.
Publicado: (2023)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
por: Liu, Xiaoyan, et al.
Publicado: (2019)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
por: Ishida, Tomoaki, et al.
Publicado: (2021)

Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia
por: Hosny, Khaled M., et al.
Publicado: (2022)

Utilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line
por: Felimban, Raed I., et al.
Publicado: (2022)

Enhancement of Haloperidol Binding Affinity to Dopamine Receptor via Forming a Charge-Transfer Complex with Picric Acid and 7,7,8,8-Tetracyanoquinodimethane for Improvement of the Antipsychotic Efficacy
por: Alamri, Abdulhakeem S., et al.
Publicado: (2022)

Association Between NR3C1 Gene Polymorphisms and Toxicity Induced by Glucocorticoids Therapy in Saudi Children with Acute Lymphoblastic Leukemia
por: El-Fayoumi, Refaat, et al.
Publicado: (2018)

Preparation and Optimization of Garlic Oil/Apple Cider Vinegar Nanoemulsion Loaded with Minoxidil to Treat Alopecia
por: Rizg, Waleed Y., et al.
Publicado: (2021)

Isocitrate dehydrogenase mutations: new opportunities for translational research
por: Keum, Young-Sam, et al.
Publicado: (2015)

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
por: Al-Khallaf, Hamoud
Publicado: (2017)

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
por: Golub, Danielle, et al.
Publicado: (2019)

Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma
por: Mellinghoff, Ingo K., et al.
Publicado: (2020)

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma
por: Alzial, Gabriel, et al.
Publicado: (2021)

Isocitrate dehydrogenase gene variants in cancer and their clinical significance
por: Cadoux-Hudson, Thomas, et al.
Publicado: (2021)

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
por: Hvinden, Ingvild Comfort, et al.
Publicado: (2021)

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
por: Liu, Yang, et al.
Publicado: (2023)

The Prognostic Value of the Developmental Gene FZD6 in Young Saudi Breast Cancer Patients: A Biomarkers Discovery and Cancer Inducers OncoScreen Approach
por: Assidi, Mourad, et al.
Publicado: (2022)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP(+)-dependent isocitrate dehydrogenase (IDH)
por: Yang, Jinsung, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1pf5msjcbt9c3ob22rtm0l4kp5