Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice

AMP-activated protein kinase (AMPK) has an important role in cellular energy homeostasis and has emerged as a promising target for treatment of Type 2 Diabetes (T2D) due to its beneficial effects on insulin sensitivity and glucose homeostasis. O304 is a pan-AMPK activator that has been shown to impr...

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Detalles Bibliográficos
Autores principales: López-Pérez, Ana, Norlin, Stefan, Steneberg, Pär, Remeseiro, Silvia, Edlund, Helena, Hörnblad, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702551/
https://www.ncbi.nlm.nih.gov/pubmed/34949756
http://dx.doi.org/10.1038/s41598-021-03567-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702551/
https://www.ncbi.nlm.nih.gov/pubmed/34949756
http://dx.doi.org/10.1038/s41598-021-03567-3

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