The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma Cells

Overexpression of the deubiquitinase USP2a leads to stabilization of fatty acid synthase (FAS), the levels of which are often elevated in aggressive human cancers. Consequently, there is an urgent need for inhibitors to suppress the deubiquitination activity of USP2a so as to upregulate FAS protein...

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Detalles Bibliográficos
Autores principales: Cheng, Chiao-Pei, Liu, Shu-Ting, Chiu, Yi-Lin, Huang, Shih-Ming, Ho, Ching-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702617/
https://www.ncbi.nlm.nih.gov/pubmed/34956872
http://dx.doi.org/10.3389/fonc.2021.749661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702617/
https://www.ncbi.nlm.nih.gov/pubmed/34956872
http://dx.doi.org/10.3389/fonc.2021.749661

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