Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer

Histone deacetylase inhibitors (HDACi) sensitize homologous recombination (HR)-proficient human ovarian cancer cells to PARP inhibitors (PARPi). To investigate mechanisms of anti-tumor effects of combined HDACi/PARPi treatment we performed transcriptome analysis in HR- proficient human ovarian cance...

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Detalles Bibliográficos
Autores principales: Wilson, Andrew J., Gupta, Vijayalaxmi G, Liu, Qi, Yull, Fiona, Crispens, Marta A., Khabele, Dineo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702851/
https://www.ncbi.nlm.nih.gov/pubmed/34933276
http://dx.doi.org/10.1016/j.neo.2021.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702851/
https://www.ncbi.nlm.nih.gov/pubmed/34933276
http://dx.doi.org/10.1016/j.neo.2021.12.002

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