Residues R1075, D1090, R1095, and C1130 Are Critical in ADAMTS13 TSP8-Spacer Interaction Predicted by Molecular Dynamics Simulation

ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin type 1 repeats, member 13) cleaves von Willebrand Factor (VWF) multimers to limit the prothrombotic function of VWF. The deficiency of ADAMTS13 causes a lethal thrombotic microvascular disease, thrombotic thrombocytopenic purpura (TTP)....

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Detalles Bibliográficos
Autores principales: Wu, Zhiwei, Yang, Junxian, Xie, Xubin, Liu, Guangjian, Fang, Ying, Wu, Jianhua, Lin, Jiangguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703438/
https://www.ncbi.nlm.nih.gov/pubmed/34946607
http://dx.doi.org/10.3390/molecules26247525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703438/
https://www.ncbi.nlm.nih.gov/pubmed/34946607
http://dx.doi.org/10.3390/molecules26247525

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