Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor

ABCB1/P-glycoprotein is an ATP binding cassette transporter that is involved in the clearance of xenobiotics, and it affects the disposition of many drugs in the body. Conformational flexibility of the protein within the membrane is an intrinsic part of its mechanism of action, but this has made str...

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Detalles Bibliográficos
Autores principales: Barbieri, Alessandro, Thonghin, Nopnithi, Shafi, Talha, Prince, Stephen M., Collins, Richard F., Ford, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703531/
https://www.ncbi.nlm.nih.gov/pubmed/34940424
http://dx.doi.org/10.3390/membranes11120923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703531/
https://www.ncbi.nlm.nih.gov/pubmed/34940424
http://dx.doi.org/10.3390/membranes11120923

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