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Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor
ABCB1/P-glycoprotein is an ATP binding cassette transporter that is involved in the clearance of xenobiotics, and it affects the disposition of many drugs in the body. Conformational flexibility of the protein within the membrane is an intrinsic part of its mechanism of action, but this has made str...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703531/ https://www.ncbi.nlm.nih.gov/pubmed/34940424 http://dx.doi.org/10.3390/membranes11120923 |