Negligible Effect of Quercetin in the Pharmacokinetics of Sulfasalazine in Rats and Beagles: Metabolic Inactivation of the Interaction Potential of Quercetin with BCRP

Breast cancer resistance protein (BCRP) mediates pharmacokinetic drug interactions. This study evaluated the potential of quercetin to inhibit and induce BCRP in vitro and in vivo. The inhibition of BCRP was investigated for quercetin and its metabolites using BCRP/mBcrp1-overexpressing MDCKII cells...

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Detalles Bibliográficos
Autores principales: Oh, Ju-Hee, Kim, Dokeun, Lee, Haejun, Kim, Gyeonghee, Park, Taehoon, Kim, Min Chang, Lee, Young-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703684/
https://www.ncbi.nlm.nih.gov/pubmed/34959273
http://dx.doi.org/10.3390/pharmaceutics13121989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703684/
https://www.ncbi.nlm.nih.gov/pubmed/34959273
http://dx.doi.org/10.3390/pharmaceutics13121989

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