Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy
Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with recapitulation of fetal-like reprogramming, which eventually results in organ failure. Analogies seem to exist between the damag...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703810/ https://www.ncbi.nlm.nih.gov/pubmed/34945151 http://dx.doi.org/10.3390/jcm10245855 |
_version_ | 1784621554232983552 |
---|---|
author | Lourbopoulos, Athanasios I. Mourouzis, Iordanis S. Trikas, Athanasios G. Tseti, Ioulia K. Pantos, Constantinos I. |
author_facet | Lourbopoulos, Athanasios I. Mourouzis, Iordanis S. Trikas, Athanasios G. Tseti, Ioulia K. Pantos, Constantinos I. |
author_sort | Lourbopoulos, Athanasios I. |
collection | PubMed |
description | Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with recapitulation of fetal-like reprogramming, which eventually results in organ failure. Analogies seem to exist between the damaged hypoxic and developing organs, indicating that a regulatory network which drives embryonic organ development may control aspects of heart (or tissue) repair. In this context, thyroid hormone (TH), which is a critical regulator of organ maturation, physiologic angiogenesis, and mitochondrial biogenesis during fetal development, may be of important physiological relevance upon stress (hypoxia)-induced fetal reprogramming. TH signaling has been implicated in hypoxic tissue remodeling after myocardial infarction and T3 prevents remodeling of the postinfarcted heart. Similarly, preliminary experimental evidence suggests that T3 can prevent early tissue hypoxia during sepsis with important physiological consequences. Thus, based on common pathways between different paradigms, we propose a possible role of TH in tissue hypoxia after sepsis with the potential to reduce secondary organ failure. |
format | Online Article Text |
id | pubmed-8703810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87038102021-12-25 Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy Lourbopoulos, Athanasios I. Mourouzis, Iordanis S. Trikas, Athanasios G. Tseti, Ioulia K. Pantos, Constantinos I. J Clin Med Review Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with recapitulation of fetal-like reprogramming, which eventually results in organ failure. Analogies seem to exist between the damaged hypoxic and developing organs, indicating that a regulatory network which drives embryonic organ development may control aspects of heart (or tissue) repair. In this context, thyroid hormone (TH), which is a critical regulator of organ maturation, physiologic angiogenesis, and mitochondrial biogenesis during fetal development, may be of important physiological relevance upon stress (hypoxia)-induced fetal reprogramming. TH signaling has been implicated in hypoxic tissue remodeling after myocardial infarction and T3 prevents remodeling of the postinfarcted heart. Similarly, preliminary experimental evidence suggests that T3 can prevent early tissue hypoxia during sepsis with important physiological consequences. Thus, based on common pathways between different paradigms, we propose a possible role of TH in tissue hypoxia after sepsis with the potential to reduce secondary organ failure. MDPI 2021-12-14 /pmc/articles/PMC8703810/ /pubmed/34945151 http://dx.doi.org/10.3390/jcm10245855 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lourbopoulos, Athanasios I. Mourouzis, Iordanis S. Trikas, Athanasios G. Tseti, Ioulia K. Pantos, Constantinos I. Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy |
title | Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy |
title_full | Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy |
title_fullStr | Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy |
title_full_unstemmed | Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy |
title_short | Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy |
title_sort | effects of thyroid hormone on tissue hypoxia: relevance to sepsis therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703810/ https://www.ncbi.nlm.nih.gov/pubmed/34945151 http://dx.doi.org/10.3390/jcm10245855 |
work_keys_str_mv | AT lourbopoulosathanasiosi effectsofthyroidhormoneontissuehypoxiarelevancetosepsistherapy AT mourouzisiordaniss effectsofthyroidhormoneontissuehypoxiarelevancetosepsistherapy AT trikasathanasiosg effectsofthyroidhormoneontissuehypoxiarelevancetosepsistherapy AT tsetiiouliak effectsofthyroidhormoneontissuehypoxiarelevancetosepsistherapy AT pantosconstantinosi effectsofthyroidhormoneontissuehypoxiarelevancetosepsistherapy |