A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

[Image: see text] Tau is a microtubule-associated protein that regulates the stability of microtubules. We use metainference cryoelectron microscopy, an integrative structural biology approach, to determine an ensemble of conformations representing the structure and dynamics of a tau-microtubule com...

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Detalles Bibliográficos
Autores principales: Brotzakis, Z. Faidon, Lindstedt, Philip R., Taylor, Ross J., Rinauro, Dillon J., Gallagher, Nicholas C. T., Bernardes, Gonçalo J. L., Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704032/
https://www.ncbi.nlm.nih.gov/pubmed/34963892
http://dx.doi.org/10.1021/acscentsci.1c00585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704032/
https://www.ncbi.nlm.nih.gov/pubmed/34963892
http://dx.doi.org/10.1021/acscentsci.1c00585

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