Extent of MGMT promoter methylation modifies the effect of temozolomide on overall survival in patients with glioblastoma: a regional cohort study

BACKGROUND: MGMT methylation in glioblastoma predicts response to temozolomide but dichotomizing methylation status may mask the true prognostic value of quantitative MGMT methylation. This study evaluated whether extent of MGMT methylation interacts with the effect of temozolomide on overall surviv...

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Detalles Bibliográficos
Autores principales: Poon, Michael T C, Keni, Shivank, Vimalan, Vineeth, Ip, Chak, Smith, Colin, Erridge, Sara, Weir, Christopher J, Brennan, Paul M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704383/
https://www.ncbi.nlm.nih.gov/pubmed/34988453
http://dx.doi.org/10.1093/noajnl/vdab171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704383/
https://www.ncbi.nlm.nih.gov/pubmed/34988453
http://dx.doi.org/10.1093/noajnl/vdab171

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