New Synthetic Lethality Re-Sensitizing Platinum-Refractory Cancer Cells to Cisplatin In Vitro: The Rationale to Co-Use PARP and ATM Inhibitors

The pro-apoptotic tumor suppressor BIN1 inhibits the activities of the neoplastic transcription factor MYC, poly (ADP-ribose) polymerase-1 (PARP1), and ATM Ser/Thr kinase (ATM) by separate mechanisms. Although BIN1 deficits increase cancer-cell resistance to DNA-damaging chemotherapeutics, such as c...

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Detalles Bibliográficos
Autores principales: Folk, Watson P., Kumari, Alpana, Iwasaki, Tetsushi, Cassimere, Erica K., Pyndiah, Slovénie, Martin, Elizabeth, Homlar, Kelly, Sakamuro, Daitoku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704450/
https://www.ncbi.nlm.nih.gov/pubmed/34948122
http://dx.doi.org/10.3390/ijms222413324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704450/
https://www.ncbi.nlm.nih.gov/pubmed/34948122
http://dx.doi.org/10.3390/ijms222413324

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