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Amino acid primed mTOR activity is essential for heart regeneration

Heart disease is the leading cause of death with no method to repair damaged myocardium due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates and zebrafish can regenerate their hearts via cardiomyocyte de-differentiation and proliferation. However, a molecular...

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Detalles Bibliográficos
Autores principales: Miklas, Jason W., Levy, Shiri, Hofsteen, Peter, Mex, Diego Ic, Clark, Elisa, Muster, Jeanot, Robitaille, Aaron M., Sivaram, Gargi, Abell, Lauren, Goodson, Jamie M., Pranoto, Inez, Madan, Anup, Chin, Michael T., Tian, Rong, Murry, Charles E., Moon, Randall T., Wang, Yuliang, Ruohola-Baker, Hannele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704488/
https://www.ncbi.nlm.nih.gov/pubmed/34988408
http://dx.doi.org/10.1016/j.isci.2021.103574