O-GlcNAcylation Inhibits Endocytosis of Amyloid Precursor Protein by Decreasing Its Localization in Lipid Raft Microdomains

Like protein phosphorylation, O-GlcNAcylation is a common post-translational protein modification. We already reported that O-GlcNAcylation of amyloid precursor protein (APP) in response to insulin signaling reduces neurotoxic amyloid-β (Aβ) production via inhibition of APP endocytosis. Internalized...

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Detalles Bibliográficos
Autores principales: Kwon, Oh-Hoon, Cho, Yoon Young, Lee, Jung Hee, Chung, Sungkwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704492/
https://www.ncbi.nlm.nih.gov/pubmed/34940409
http://dx.doi.org/10.3390/membranes11120909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704492/
https://www.ncbi.nlm.nih.gov/pubmed/34940409
http://dx.doi.org/10.3390/membranes11120909

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