The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease

Alpha-1 antitrypsin deficiency (AATD) is caused by a single mutation in the SERPINA1 gene, which culminates in the accumulation of misfolded alpha-1 antitrypsin (ZAAT) within the endoplasmic reticulum (ER) of hepatocytes. AATD is associated with liver disease resulting from hepatocyte injury due to...

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Detalles Bibliográficos
Autores principales: Khodayari, Nazli, Wang, Rejean L., Oshins, Regina, Lu, Yuanqing, Millett, Michael, Aranyos, Alek M., Mostofizadeh, Sayedamin, Scindia, Yogesh, Flagg, Tammy O., Brantly, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704552/
https://www.ncbi.nlm.nih.gov/pubmed/34948056
http://dx.doi.org/10.3390/ijms222413255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704552/
https://www.ncbi.nlm.nih.gov/pubmed/34948056
http://dx.doi.org/10.3390/ijms222413255

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