Synthesis, Molecular Docking Analysis, and Biological Evaluations of Saccharide-Modified Sulfonamides as Carbonic Anhydrase IX Inhibitors

Based on the strategy of the “tail approach”, 15 novel saccharide-modified sulfonamides were designed and synthesised. The novel compounds were evaluated as inhibitors of three human carbonic anhydrase (CA) isoforms, namely cytoplasmic CA II, transmembrane CA IX, and XII. Most of these compounds sho...

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Detalles Bibliográficos
Autores principales: Zhang, Zuopeng, Yang, Huali, Zhong, Ye, Wang, Yueqing, Wang, Jian, Cheng, Maosheng, Liu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704611/
https://www.ncbi.nlm.nih.gov/pubmed/34948406
http://dx.doi.org/10.3390/ijms222413610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704611/
https://www.ncbi.nlm.nih.gov/pubmed/34948406
http://dx.doi.org/10.3390/ijms222413610

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