Canagliflozin Modulates Hypoxia-Induced Metastasis, Angiogenesis and Glycolysis by Decreasing HIF-1α Protein Synthesis via AKT/mTOR Pathway

The microenvironment plays a vital role in tumor progression, and hypoxia is a typical microenvironment feature in nearly all solid tumors. In this study, we focused on elucidating the effect of canagliflozin (CANA), a new class of antidiabetic agents, on hepatocarcinoma (HCC) tumorigenesis under hy...

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Detalles Bibliográficos
Autores principales: Luo, Jingyi, Sun, Pengbo, Zhang, Xun, Lin, Guanglan, Xin, Qilei, Niu, Yaoyun, Chen, Yang, Xu, Naihan, Zhang, Yaou, Xie, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704642/
https://www.ncbi.nlm.nih.gov/pubmed/34948132
http://dx.doi.org/10.3390/ijms222413336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704642/
https://www.ncbi.nlm.nih.gov/pubmed/34948132
http://dx.doi.org/10.3390/ijms222413336

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