Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Three open-source anti-kinetoplastid chemical boxes derived from a whole-cell phenotypic screening by GlaxoSmithKline (Tres Cantos Anti-Kinetoplastid Screening, TCAKS) were exploited for the discovery of a novel core structure inspiring new treatments of parasitic diseases targeting the trypansosmat...

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Detalles Bibliográficos
Autores principales: Santucci, Matteo, Luciani, Rosaria, Gianquinto, Eleonora, Pozzi, Cecilia, Pisa, Flavio di, dello Iacono, Lucia, Landi, Giacomo, Tagliazucchi, Lorenzo, Mangani, Stefano, Spyrakis, Francesca, Costi, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704748/
https://www.ncbi.nlm.nih.gov/pubmed/34959646
http://dx.doi.org/10.3390/ph14121246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704748/
https://www.ncbi.nlm.nih.gov/pubmed/34959646
http://dx.doi.org/10.3390/ph14121246

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