CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export

We report here two genome-wide CRISPR screens performed to identify genes that, when knocked out, alter levels of lysosomal cholesterol or bis(monoacylglycero)phosphate. In addition, these screens were also performed under conditions of NPC1 inhibition to identify modifiers of NPC1 function in lysos...

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Detalles Bibliográficos
Autores principales: Lu, Albert, Hsieh, Frank, Sharma, Bikal R., Vaughn, Sydney R., Enrich, Carlos, Pfeffer, Suzanne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704955/
https://www.ncbi.nlm.nih.gov/pubmed/34936700
http://dx.doi.org/10.1083/jcb.202105060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704955/
https://www.ncbi.nlm.nih.gov/pubmed/34936700
http://dx.doi.org/10.1083/jcb.202105060

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