Sarm1 activation produces cADPR to increase intra-axonal Ca(++) and promote axon degeneration in PIPN

Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder. Pathologically, CIPN is characterized by a “dying-back” axonopathy that...

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Detalles Bibliográficos
Autores principales: Li, Yihang, Pazyra-Murphy, Maria F., Avizonis, Daina, de Sá Tavares Russo, Mariana, Tang, Sophia, Chen, Chiung-Ya, Hsueh, Yi-Ping, Bergholz, Johann S., Jiang, Tao, Zhao, Jean J., Zhu, Jian, Ko, Kwang Woo, Milbrandt, Jeffrey, DiAntonio, Aaron, Segal, Rosalind A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704956/
https://www.ncbi.nlm.nih.gov/pubmed/34935867
http://dx.doi.org/10.1083/jcb.202106080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704956/
https://www.ncbi.nlm.nih.gov/pubmed/34935867
http://dx.doi.org/10.1083/jcb.202106080

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