The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors

α-Conotoxins GI and MI belong to the 3/5 subfamily of α-conotoxins and potently inhibit muscular nicotinic acetylcholine receptors (nAChRs). To date, no 3/4- or 3/6-subfamily α-conotoxins have been reported to inhibit muscular nAChRs. In the present study, a series of new 3/4-, 3/6-, and 3/7-subfami...

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Detalles Bibliográficos
Autores principales: Ma, Xiaoli, Huang, Qiuyuan, Yu, Shuo, Xu, Shujing, Huang, Yue, Zhao, Zhiming, Xiao, Xinrong, Dai, Qiuyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704989/
https://www.ncbi.nlm.nih.gov/pubmed/34940704
http://dx.doi.org/10.3390/md19120705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704989/
https://www.ncbi.nlm.nih.gov/pubmed/34940704
http://dx.doi.org/10.3390/md19120705

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