Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS

Succinate is a metabolite in the tricarboxylic acid cycle (TCA) which plays a central role in mitochondrial activity. Excess succinate is known to be transported out of the cytosol, where it activates a succinate receptor (SUCNR1) to enhance inflammation through macrophages in various contexts. In a...

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Detalles Bibliográficos
Autores principales: Wang, Lixiang, Zhang, Yanli, Kiprowska, Magdalena, Guo, Yuqi, Yamamoto, Ken, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705220/
https://www.ncbi.nlm.nih.gov/pubmed/34940612
http://dx.doi.org/10.3390/metabo11120854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705220/
https://www.ncbi.nlm.nih.gov/pubmed/34940612
http://dx.doi.org/10.3390/metabo11120854

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