Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions

Apoptosis signal-regulating kinase (ASK) 1, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, modulates diverse responses to oxidative and endoplasmic reticulum (ER) stress and calcium influx. As a crucial cellular stress sensor, ASK1 activates c-Jun N-terminal kinases (...

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Detalles Bibliográficos
Autores principales: Obsilova, Veronika, Honzejkova, Karolina, Obsil, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705584/
https://www.ncbi.nlm.nih.gov/pubmed/34948191
http://dx.doi.org/10.3390/ijms222413395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705584/
https://www.ncbi.nlm.nih.gov/pubmed/34948191
http://dx.doi.org/10.3390/ijms222413395

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