Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid

The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent cytokine release in a tumour-bearing humanised mouse model. Pharmacokinetics (PK)...

Descripción completa

Detalles Bibliográficos
Autores principales: Eigenmann, Miro Julian, Karlsen, Tine Veronica, Wagner, Marek, Tenstad, Olav, Weinzierl, Tina, Fauti, Tanja, Grimm, Hans Peter, Skogstrand, Trude, Klein, Christian, Sam, Johannes, Umana, Pablo, Bacac, Marina, Wiig, Helge, Walz, Antje-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705663/
https://www.ncbi.nlm.nih.gov/pubmed/34959386
http://dx.doi.org/10.3390/pharmaceutics13122105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705663/
https://www.ncbi.nlm.nih.gov/pubmed/34959386
http://dx.doi.org/10.3390/pharmaceutics13122105

Ejemplares similares