Discovery of Octahydroisoindolone as a Scaffold for the Selective Inhibition of Chitinase B1 from Aspergillus fumigatus: In Silico Drug Design Studies

Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they are necessary for fungal cell wall remodeling. This study presents the design of new chitinase inhibitors from a known hydrolysis intermediate. Firstly, a bioinformatic analysis of Aspergillus fumiga...

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Detalles Bibliográficos
Autores principales: Marbán-González, Alberto, Hernández-Mendoza, Armando, Ordóñez, Mario, Razo-Hernández, Rodrigo Said, Viveros-Ceballos, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705689/
https://www.ncbi.nlm.nih.gov/pubmed/34946697
http://dx.doi.org/10.3390/molecules26247606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705689/
https://www.ncbi.nlm.nih.gov/pubmed/34946697
http://dx.doi.org/10.3390/molecules26247606

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