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Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures

Epilepsy is a complex disorder affecting the central nervous system and is characterised by spontaneously recurring seizures (SRSs). Epileptic patients undergo symptomatic pharmacological treatments, however, in 30% of cases, they are ineffective, mostly in patients with temporal lobe epilepsy. Ther...

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Detalles Bibliográficos
Autores principales: Waloschková, Eliška, Gonzalez-Ramos, Ana, Mikroulis, Apostolos, Kudláček, Jan, Andersson, My, Ledri, Marco, Kokaia, Merab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705828/
https://www.ncbi.nlm.nih.gov/pubmed/34948040
http://dx.doi.org/10.3390/ijms222413243