INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN). Dolutegravir (DTG) is a leading INSTI that is given, usually in combination with nucle...

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Detalles Bibliográficos
Autores principales: Smith, Steven J., Ferris, Andrea, Zhao, Xuezhi, Pauly, Gary, Schneider, Joel P., Burke, Terrence R., Hughes, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705849/
https://www.ncbi.nlm.nih.gov/pubmed/34960770
http://dx.doi.org/10.3390/v13122501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705849/
https://www.ncbi.nlm.nih.gov/pubmed/34960770
http://dx.doi.org/10.3390/v13122501

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