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INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN). Dolutegravir (DTG) is a leading INSTI that is given, usually in combination with nucle...
Autores principales: | Smith, Steven J., Ferris, Andrea, Zhao, Xuezhi, Pauly, Gary, Schneider, Joel P., Burke, Terrence R., Hughes, Stephen H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705849/ https://www.ncbi.nlm.nih.gov/pubmed/34960770 http://dx.doi.org/10.3390/v13122501 |
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