Cargando…

The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine

α-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson’s Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramirez, Alejandra E., Fernández-Pérez, Eduardo J., Olivos, Nicol, Burgos, Carlos F., Boopathi, Subramanian, Armijo-Weingart, Lorena, Pacheco, Carla R., González, Wendy, Aguayo, Luis G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705949/ https://www.ncbi.nlm.nih.gov/pubmed/34948050 http://dx.doi.org/10.3390/ijms222413253

Ejemplares similares

Aging in nucleus accumbens and its impact on alcohol use disorders
por: Konar-Nié, Macarena, et al.
Publicado: (2023)

Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer’s disease mouse model
por: Fernández-Pérez, E. J., et al.
Publicado: (2020)

Use of stimulatory responsive soft nanoparticles for intracellular drug delivery
por: Hughes, Krystal A., et al.
Publicado: (2023)

Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens
por: San Martin, Loreto S., et al.
Publicado: (2021)

Neurotrophins induce fission of mitochondria along embryonic sensory axons
por: Armijo-Weingart, Lorena, et al.
Publicado: (2019)

The Synaptic Function of α-Synuclein
por: Burré, Jacqueline
Publicado: (2015)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
por: Sun, Jichao, et al.
Publicado: (2019)

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain
por: Pacheco, C., et al.
Publicado: (2012)

Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers
por: Fernandez‐Perez, Eduardo J., et al.
Publicado: (2021)

Intracellular Alpha-Synuclein and Immune Cell Function
por: Grozdanov, Veselin, et al.
Publicado: (2020)

Editorial: Intracellular Mechanisms of α-Synuclein Processing
por: Zunke, Friederike, et al.
Publicado: (2021)

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
por: Ghiglieri, Veronica, et al.
Publicado: (2018)

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
por: Gallegos, Scarlet, et al.
Publicado: (2015)

Structural basis of synaptic vesicle assembly promoted by α-synuclein
por: Fusco, Giuliana, et al.
Publicado: (2016)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Brain Inflammation and Intracellular α-Synuclein Aggregates in Macaques after SARS-CoV-2 Infection
por: Philippens, Ingrid H. C. H. M., et al.
Publicado: (2022)

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein
por: Fusco, Giuliana, et al.
Publicado: (2017)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
por: Heras-Garvin, Antonio, et al.
Publicado: (2020)

Synuclein Regulates Synaptic Vesicle Clustering and Docking at a Vertebrate Synapse
por: Fouke, Kaitlyn E., et al.
Publicado: (2021)

Alpha‐Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction
por: Ponterio, Giulia, et al.
Publicado: (2022)

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
por: Lai, Ying, et al.
Publicado: (2023)

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein
por: Janowska, Maria K., et al.
Publicado: (2015)

A direct stimulatory role of mobile gibberellin in Arabidopsis hypocotyl xylem expansion
por: Nieminen, Kaisa, et al.
Publicado: (2011)

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease
por: Lamonaca, Giulia, et al.
Publicado: (2020)

Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF
por: Boiten, Walter A., et al.
Publicado: (2020)

CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington’s disease
por: Yu, Dahyun, et al.
Publicado: (2022)

Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability
por: Kaufmann, Timothy J., et al.
Publicado: (2016)

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
por: Booms, Alix, et al.
Publicado: (2021)

Microglial Intracellular Ca(2+) Signaling in Synaptic Development and its Alterations in Neurodevelopmental Disorders
por: Mizoguchi, Yoshito, et al.
Publicado: (2017)

IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson’s disease models
por: Arcos, Javiera, et al.
Publicado: (2023)

T-cell co-stimulatory pathways in autoimmunity
por: Goronzy, Jörg J, et al.
Publicado: (2008)

Immunotherapies targeting stimulatory pathways and beyond
por: Marin-Acevedo, Julian A., et al.
Publicado: (2021)

Stimulatory effect of imeglimin on incretin secretion
por: Yingyue, Quan, et al.
Publicado: (2023)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function
por: Plotegher, N., et al.
Publicado: (2017)

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
por: Amorim, Inês S., et al.
Publicado: (2017)

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour
por: Breda, Carlo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n7es0j6nm7sa5e3q29n1372u65