A Search for Cyclin-Dependent Kinase 4/6 Inhibitors by Pharmacophore-Based Virtual Screening, Molecular Docking, and Molecular Dynamic Simulations

The G1 phase of cell cycle progression is regulated by Cyclin-Dependent Kinase 4 (CDK4) as well as Cyclin-Dependent Kinase 6 (CDK6), and the acivities of these enzymes are regulated by the catalytic subunit, cyclin D. Cell cycle control through selective pharmacological inhibition of CDK4/6 has prov...

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Detalles Bibliográficos
Autores principales: Susanti, Ni Made Pitri, Damayanti, Sophi, Kartasasmita, Rahmana Emran, Tjahjono, Daryono Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706085/
https://www.ncbi.nlm.nih.gov/pubmed/34948218
http://dx.doi.org/10.3390/ijms222413423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706085/
https://www.ncbi.nlm.nih.gov/pubmed/34948218
http://dx.doi.org/10.3390/ijms222413423

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