Aurintricarboxylic Acid Decreases RNA Toxicity in a C. elegans Model of Repeat Expansions

Pathologic expansions of DNA nucleotide tandem repeats may generate toxic RNA that triggers disease phenotypes. RNA toxicity is the hallmark of multiple expansion repeat disorders, including myotonic dystrophy type 1 (DM1). To date, there are no available disease-modifying therapies for DM1. Our aim...

Descripción completa

Detalles Bibliográficos
Autores principales: Braun, Maya, Shoshani, Shachar, Mellul-Shtern, Anna, Tabach, Yuval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706575/
https://www.ncbi.nlm.nih.gov/pubmed/34941747
http://dx.doi.org/10.3390/toxins13120910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706575/
https://www.ncbi.nlm.nih.gov/pubmed/34941747
http://dx.doi.org/10.3390/toxins13120910

Ejemplares similares