Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma

Glioblastoma (GBM) is the most malignant and aggressive form of glioma and is associated with a poor survival rate. Latest generation Tumour Necrosis Factor Related Apoptosis-Inducing Ligand (TRAIL)-based therapeutics potently induce apoptosis in cancer cells, including GBM cells, by binding to deat...

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Detalles Bibliográficos
Autores principales: Krishna Moorthy, Nivetha, Seifert, Oliver, Eisler, Stephan, Weirich, Sara, Kontermann, Roland E., Rehm, Markus, Fullstone, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706683/
https://www.ncbi.nlm.nih.gov/pubmed/34946664
http://dx.doi.org/10.3390/molecules26247582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706683/
https://www.ncbi.nlm.nih.gov/pubmed/34946664
http://dx.doi.org/10.3390/molecules26247582

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