Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor

Neurofibromatosis type 1 (NF1) is an autosomal dominant human genetic disorder. The progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors (MPNSTs) is a major cause of mortality in patients with NF1. Although elevated epidermal growth factor receptor (EGFR) expressi...

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Detalles Bibliográficos
Autores principales: Park, Gun-Hoo, Lee, Su-Jin, Lee, Chang-Gun, Kim, Jeonghyun, Park, Eunkuk, Jeong, Seon-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706697/
https://www.ncbi.nlm.nih.gov/pubmed/34948100
http://dx.doi.org/10.3390/ijms222413308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706697/
https://www.ncbi.nlm.nih.gov/pubmed/34948100
http://dx.doi.org/10.3390/ijms222413308

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