Cargando…

Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles

(1) Background: T cells are important target cells, since they exert direct cytotoxic effects on infected/malignant cells, and affect the regulatory functions of other immune cells in a target antigen-specific manner. One of the current approaches for modifying the function of T cells is gene transf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanaka, Hiroki, Miyama, Ryo, Sakurai, Yu, Tamagawa, Shinya, Nakai, Yuta, Tange, Kota, Yoshioka, Hiroki, Akita, Hidetaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706876/ https://www.ncbi.nlm.nih.gov/pubmed/34959378 http://dx.doi.org/10.3390/pharmaceutics13122097

Ejemplares similares

Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material
por: Tanaka, Hiroki, et al.
Publicado: (2021)

The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds
por: Tanaka, Hiroki, et al.
Publicado: (2018)

Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis
por: Gomi, Masaki, et al.
Publicado: (2023)

Development of an Alcohol Dilution–Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability
por: Shirane, Daiki, et al.
Publicado: (2023)

An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses
por: Oyama, Ryotaro, et al.
Publicado: (2023)

pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells
por: Sakurai, Yu, et al.
Publicado: (2022)

Intracellular Drug Delivery Process of Am80-Encapsulated Lipid Nanoparticles Aiming for Alveolar Regeneration
por: Akita, Tomomi, et al.
Publicado: (2023)

Am80-Encapsulated Lipid Nanoparticles, Developed with the Aim of Achieving Alveolar Regeneration, Have an Improvement Effect on Pulmonary Emphysema
por: Akita, Tomomi, et al.
Publicado: (2022)

Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery
por: Du, Xuan, et al.
Publicado: (2023)

PEG–lipid–PLGA hybrid nanoparticles loaded with berberine–phospholipid complex to facilitate the oral delivery efficiency
por: Yu, Fei, et al.
Publicado: (2017)

Component and Content of Lipid Classes and Phospholipid Molecular Species of Eggs and Body of the Vietnamese Sea Urchin Tripneustes gratilla
por: Dinh, Thi-Kim-Hoa, et al.
Publicado: (2023)

A Lipid Nanoparticle-Based Method for the Generation of Liver-Specific Knockout Mice
por: Morita, Sumiyo, et al.
Publicado: (2023)

Lipid Signaling in Ocular Neovascularization
por: Terao, Ryo, et al.
Publicado: (2020)

THE STABILIZATION OF SERUM LIPID EMULSIONS BY SERUM PHOSPHOLIPIDS
por: Ahrens, Edward H., et al.
Publicado: (1949)

Phospholipid and Lipid Derivatives as Potential Neuroprotective Compounds
por: Tayebati, Seyed Khosrow
Publicado: (2018)

Comparison of Workflows for Milk Lipid Analysis: Phospholipids
por: Li, Cheng, et al.
Publicado: (2022)

Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates
por: Suzuki, Yuta, et al.
Publicado: (2022)

Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism
por: Lujan, Agustin Leonardo, et al.
Publicado: (2023)

Changing the phospholipid composition of lipid droplets alters localization of select lipid droplet proteins
por: Renier, Timothy J., et al.
Publicado: (2023)

PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration
por: Kurimoto, Shota, et al.
Publicado: (2019)

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
por: Sakuragi, Takaharu, et al.
Publicado: (2023)

Phospholipid Preparations to Characterize Protein–Lipid Interactions In Vitro
por: Merklinger, Lisa, et al.
Publicado: (2023)

Enhanced avidin binding to lipid bilayers using PDP-PE lipids with PEG-biotin linkers
por: Birchenough, Holly L., et al.
Publicado: (2020)

Toxoplasma gondii GRA15 DNA Vaccine with a Liposomal Nanocarrier Composed of an SS-Cleavable and pH-Activated Lipid-like Material Induces Protective Immunity against Toxoplasmosis in Mice
por: Hasan, Tanjila, et al.
Publicado: (2021)

Optimization of Sentinel Lymph Node Imaging Methodology Using Anionic Liposome and Hyaluronidase
por: Sakurai, Yu, et al.
Publicado: (2021)

Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors
por: Cho, Riki, et al.
Publicado: (2020)

Changes in the Total Lipid, Neutral Lipid, Phospholipid and Fatty Acid Composition of Phospholipid Fractions during Pastırma Processing, a Dry-Cured Meat Product
por: Aksu, Muhammet Irfan, et al.
Publicado: (2017)

SEC14 Phospholipid Transfer Protein Is Involved in Lipid Signaling-Mediated Plant Immune Responses in Nicotiana benthamiana
por: Kiba, Akinori, et al.
Publicado: (2014)

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
por: Hall, Zoe, et al.
Publicado: (2017)

Protocol for determining the regulation of lipid kinases and changes in phospholipids in vitro
por: Karabiyik, Cansu, et al.
Publicado: (2021)

A Route to Synthesize Ionizable Lipid ALC-0315, a Key Component of the mRNA Vaccine Lipid Matrix
por: Boldyrev, I. A., et al.
Publicado: (2023)

From lipids to lipid nanoparticles to mRNA vaccines
por: Horejs, Christine
Publicado: (2021)

Development of Sentinel LN Imaging with a Combination of HAase Based on a Comprehensive Analysis of the Intra-lymphatic Kinetics of LPs
por: Gomi, Masaki, et al.
Publicado: (2021)

Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice
por: Ronda, Onne A. H. O., et al.
Publicado: (2020)

Neutral Lipid Metabolism Influences Phospholipid Synthesis and Deacylation in Saccharomyces cerevisiae
por: Mora, Gabriel, et al.
Publicado: (2012)

Anisotropic metal growth on phospholipid nanodiscs via lipid bilayer expansion
por: Oertel, Jana, et al.
Publicado: (2016)

Ligand Distribution and Lipid Phase Behavior in Phospholipid-Coated Microbubbles and Monolayers
por: Langeveld, Simone A. G., et al.
Publicado: (2020)

Acetaminophen Interactions with Phospholipid Vesicles Induced Changes in Morphology and Lipid Dynamics
por: De Mel, Judith U., et al.
Publicado: (2021)

Coral Lipidome: Molecular Species of Phospholipids, Glycolipids, Betaine Lipids, and Sphingophosphonolipids
por: Sikorskaya, Tatyana V.
Publicado: (2023)

Analysis of PEG-lipid anchor length on lipid nanoparticle pharmacokinetics and activity in a mouse model of traumatic brain injury
por: Waggoner, Lauren E., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_oiq6qp31cb2jmspse7hne64kdb