JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway

Testicular ischemia reperfusion injury (tIRI) causes oxidative stress-induced DNA damage leading to germ cell apoptosis (GCA). The aim of the study is to establish a direct link between JAK2 activation and the DNA damage response (DDR) signaling pathways and their role in tIRI-induced GCA using AG49...

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Detalles Bibliográficos
Autores principales: Khashab, Farah, Al-Saleh, Farah, Al-Kandari, Nora, Fadel, Fatemah, Al-Maghrebi, May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706947/
https://www.ncbi.nlm.nih.gov/pubmed/34948185
http://dx.doi.org/10.3390/ijms222413390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706947/
https://www.ncbi.nlm.nih.gov/pubmed/34948185
http://dx.doi.org/10.3390/ijms222413390

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