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eIF5A-Independent Role of DHPS in p21(CIP1) and Cell Fate Regulation

Deoxyhypusine synthase (DHPS) catalyzes the first step of hypusination of the elongation translation factor 5A (eIF5A), and these two proteins have an exclusive enzyme–substrate relationship. Here we demonstrate that DHPS has a role independent of eIF5A hypusination in A375 and SK-MEL-28 human melan...

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Detalles Bibliográficos
Autores principales: Becker, Andrew E., Wu, Pui-Kei, Park, Jong-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707118/
https://www.ncbi.nlm.nih.gov/pubmed/34947982
http://dx.doi.org/10.3390/ijms222413187