Phosphonodithioester–Amine Coupling as a Key Reaction Step for the Design of Cationic Amphiphiles Used for Gene Delivery

A convergent synthesis of cationic amphiphilic compounds is reported here with the use of the phosphonodithioester–amine coupling (PAC) reaction. This versatile reaction occurs at room temperature without any catalyst, allowing binding of the lipid moiety to a polar head group. This strategy is illu...

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Detalles Bibliográficos
Autores principales: Khalil, Montassar, Hocquigny, Alexis, Berchel, Mathieu, Montier, Tristan, Jaffrès, Paul-Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707180/
https://www.ncbi.nlm.nih.gov/pubmed/34946591
http://dx.doi.org/10.3390/molecules26247507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707180/
https://www.ncbi.nlm.nih.gov/pubmed/34946591
http://dx.doi.org/10.3390/molecules26247507

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