Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring

A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In general, the compounds are highly toxic to human gingival carcinoma (Ca9-22), human squamous carcinoma-2 (HSC-2) and human squamous carcinoma-4 (HSC-4) neoplasms, but less so towards non-malignant hum...

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Detalles Bibliográficos
Autores principales: Roayapalley, Praveen K., Sakagami, Hiroshi, Satoh, Keitaro, Amano, Shigeru, Bandow, Kenjiro, Aguilera, Renato J., Hernandez, Karla G. Cano, Schiaffino Bustamante, Austre Y., Dimmock, Stephen G., Sharma, Rajendra K., Das, Umashankar, Dimmock, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707244/
https://www.ncbi.nlm.nih.gov/pubmed/34940290
http://dx.doi.org/10.3390/medicines8120078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707244/
https://www.ncbi.nlm.nih.gov/pubmed/34940290
http://dx.doi.org/10.3390/medicines8120078

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