Cargando…

Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring

A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In general, the compounds are highly toxic to human gingival carcinoma (Ca9-22), human squamous carcinoma-2 (HSC-2) and human squamous carcinoma-4 (HSC-4) neoplasms, but less so towards non-malignant hum...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roayapalley, Praveen K., Sakagami, Hiroshi, Satoh, Keitaro, Amano, Shigeru, Bandow, Kenjiro, Aguilera, Renato J., Hernandez, Karla G. Cano, Schiaffino Bustamante, Austre Y., Dimmock, Stephen G., Sharma, Rajendra K., Das, Umashankar, Dimmock, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707244/ https://www.ncbi.nlm.nih.gov/pubmed/34940290 http://dx.doi.org/10.3390/medicines8120078

Ejemplares similares

Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells
por: Hossain, Mohammad, et al.
Publicado: (2022)

Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts
por: Roayapalley, Praveen K., et al.
Publicado: (2021)

Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity
por: Chhikara, Aruna, et al.
Publicado: (2022)

Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms
por: Contreras, Lisett, et al.
Publicado: (2021)

Anticonvulsant Properties of 1-Diethylamino-3-phenylprop-2-en-1-one
por: Das, Swagatika, et al.
Publicado: (2023)

Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo
por: Kudo, Chieko, et al.
Publicado: (2011)

Design, Syntheses, and Bioevaluations of Some Novel N(2)-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents
por: Lakhani, Kinjal, et al.
Publicado: (2021)

Computational and pharmacological investigation of novel 1,5-diaryl-1,4-pentadien-3-one derivatives for analgesic, anti-inflammatory and anticancer potential
por: Tariq, Muhammad Sheraz, et al.
Publicado: (2019)

Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives
por: Naitoh, Kotone, et al.
Publicado: (2022)

3-Oxo-3-(piperidin-1-yl)propanenitrile
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells
por: Selvakumar, Ponniah, et al.
Publicado: (2009)

Comparative QSAR Analysis of 3,5-bis (Arylidene)-4-Piperidone Derivatives: the Development of Predictive Cytotoxicity Models
por: Edraki, Najmeh, et al.
Publicado: (2016)

Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents
por: dos Anjos, Janaína V., et al.
Publicado: (2012)

Photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides
por: Kobiki, Yohsuke, et al.
Publicado: (2013)

Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy
por: Verza, Flávia Alves, et al.
Publicado: (2020)

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands
por: Intagliata, Sebastiano, et al.
Publicado: (2020)

The Potential Use of N-Myristoyltransferase as a Biomarker in the Early Diagnosis of Colon Cancer
por: Kumar, Sujeet, et al.
Publicado: (2011)

Homocouplings of Sodium Arenesulfinates: Selective Access to Symmetric Diaryl Sulfides and Diaryl Disulfides
por: Yu, Xin-Zhang, et al.
Publicado: (2022)

Design, Synthesis and Antifungal Activity of Novel 1,4-Pentadiene-3-one Containing Quinazolinone
por: Zhou, Ran, et al.
Publicado: (2023)

A personal perspective on returning secondary results of clinical genome sequencing
por: Dimmock, David
Publicado: (2012)

Rapid PCR Method for the Selection of 1,3-Pentadiene Non-Producing Debaryomyces hansenii Yeast Strains
por: Rivas, Eva-María, et al.
Publicado: (2020)

Bimetallic Aluminum‐ and Niobium‐Doped MCM‐41 for Efficient Conversion of Biomass‐Derived 2‐Methyltetrahydrofuran to Pentadienes
por: Fan, Mengtian, et al.
Publicado: (2022)

(7-Chloro-2-oxo-2H-chromen-4-yl)methyl piperidine-1-carbodithioate
por: Kumar, K. Mahesh, et al.
Publicado: (2012)

3-Oxo-5-(piperidin-1-yl)-2,3-dihydro-1H-pyrazole-4-carbonitrile
por: Al-Adiwish, Wedad M., et al.
Publicado: (2011)

c-3,t-3-Dimethyl-4-oxo-r-2,c-6-diphenylpiperidine-1-carboxamide
por: Thenmozhi, M., et al.
Publicado: (2009)

(3-Oxo-3H-benzo[f]chromen-1-yl)methyl piperidine-1-carbodithioate
por: Kotresh, O., et al.
Publicado: (2012)

Introduction to modern virology /
por: Dimmock, N. J.
Publicado: (2001)

Introduction to modern virology /
por: Dimmock, N. J.
Publicado: (2007)

Surgery of the Pelvic Organs
por: Dimmock, H. P.
Publicado: (1910)

Trypanosomiasis
por: Dimmock, H. P.
Publicado: (1904)

Two Cases of Splenectomy
por: Dimmock, H. P.
Publicado: (1908)

1,3-Pentadiene-Assistant Living Anionic Terpolymerization: Composition Impact on Kinetics and Microstructure Sequence Primary Analysis
por: Xiong, Qiaoqiao, et al.
Publicado: (2023)

3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl oxide
por: Zhu, Guang-Zhou, et al.
Publicado: (2011)

Sequential Diels–Alder/[3,3]-sigmatropic rearrangement reactions of β-nitrostyrene with 3-methyl-1,3-pentadiene
por: Wade, Peter A, et al.
Publicado: (2013)

Design, Synthesis and Bioactivities of Novel 1,4-Pentadien-3-one Derivatives Containing a Substituted Pyrazolyl Moiety
por: Chen, Cuili, et al.
Publicado: (2017)

Search of Neuroprotective Polyphenols Using the “Overlay” Isolation Method
por: Sakagami, Hiroshi, et al.
Publicado: (2018)

Characterization of the host–guest complex of a curcumin analog with β-cyclodextrin and β-cyclodextrin–gemini surfactant and evaluation of its anticancer activity
por: Poorghorban, Masoomeh, et al.
Publicado: (2015)

(6-Methoxy-2-oxo-2H-chromen-4-yl)methyl piperidine-1-carbodithioate
por: Kumar, K. Mahesh, et al.
Publicado: (2013)

Photo-Inactivation of Staphylococcus aureus by Diaryl-Porphyrins
por: Orlandi, Viviana Teresa, et al.
Publicado: (2023)

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers
por: Kovács, Édua, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0sf37s7r6nb0kpsg6br2bh318m