Cargando…

In Situ Cell Signalling of the Hippo-YAP/TAZ Pathway in Reaction to Complex Dynamic Loading in an Intervertebral Disc Organ Culture

Recently, a dysregulation of the Hippo-YAP/TAZ pathway has been correlated with intervertebral disc (IVD) degeneration (IDD), as it plays a key role in cell survival, tissue regeneration, and mechanical stress. We aimed to investigate the influence of different mechanical loading regimes, i.e., unde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Croft, Andreas S., Roth, Ysaline, Oswald, Katharina A. C., Ćorluka, Slavko, Bermudez-Lekerika, Paola, Gantenbein, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707270/ https://www.ncbi.nlm.nih.gov/pubmed/34948441 http://dx.doi.org/10.3390/ijms222413641

Ejemplares similares

Hippo-YAP/TAZ signaling in angiogenesis
por: Park, Jeong Ae, et al.
Publicado: (2018)

Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway
por: Wang, Yiyang, et al.
Publicado: (2021)

Hippo-Yap/Taz signalling in zebrafish regeneration
por: Riley, Susanna E., et al.
Publicado: (2022)

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
por: Dobrokhotov, Oleg, et al.
Publicado: (2018)

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin
por: Chan, Siew Wee, et al.
Publicado: (2011)

Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis
por: Boopathy, Gandhi T. K., et al.
Publicado: (2019)

Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway
por: Vanyai, Hannah K., et al.
Publicado: (2020)

Sulfated Hydrogels in Intervertebral Disc and Cartilage Research
por: Lazarus, Emily, et al.
Publicado: (2021)

Should Degenerated Intervertebral Discs of Patients with Modic Type 1 Changes Be Treated with Mesenchymal Stem Cells?
por: Herger, Nick, et al.
Publicado: (2022)

The Roles of YAP/TAZ and the Hippo Pathway in Healthy and Diseased Skin
por: Rognoni, Emanuel, et al.
Publicado: (2019)

The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling
por: Hillmer, Ryan E., et al.
Publicado: (2019)

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer
por: Benedetto, Anna Di, et al.
Publicado: (2016)

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
por: Cunningham, Richard, et al.
Publicado: (2022)

Immuno-Modulatory Effects of Intervertebral Disc Cells
por: Bermudez-Lekerika, Paola, et al.
Publicado: (2022)

Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence
por: Zhang, Cong, et al.
Publicado: (2017)

Pro-Invasive Activity of the Hippo Pathway Effectors YAP and TAZ in Cutaneous Melanoma
por: Nallet-Staub, Flore, et al.
Publicado: (2014)

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
por: Moroishi, Toshiro, et al.
Publicado: (2015)

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration
por: Lu, Li, et al.
Publicado: (2018)

Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology
por: Chen, Xiaoqing, et al.
Publicado: (2020)

Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone
por: Isfort, Ilka, et al.
Publicado: (2019)

Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View
por: Cho, Yong Suk, et al.
Publicado: (2021)

Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications
por: Sun, Tianai, et al.
Publicado: (2020)

Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ
por: Khanal, Prem, et al.
Publicado: (2018)

Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease
por: Cobbaut, Mathias, et al.
Publicado: (2020)

Molecular Mechanism of Hippo–YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration
por: Chen, Xiaoqing, et al.
Publicado: (2020)

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis
por: Wang, Haichuan, et al.
Publicado: (2020)

Transcriptional co‐activators YAP1–TAZ of Hippo signalling in doxorubicin‐induced cardiomyopathy
por: Berecz, Tünde, et al.
Publicado: (2021)

The Hippo Signaling Core Components YAP and TAZ as New Prognostic Factors in Lung Cancer
por: Jiang, Yu, et al.
Publicado: (2022)

A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
por: Cha, Boksik, et al.
Publicado: (2021)

The Hippo–YAP/TAZ Signaling Pathway in Intestinal Self-Renewal and Regeneration After Injury
por: Deng, Feihong, et al.
Publicado: (2022)

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function
por: Sun, Congshan, et al.
Publicado: (2017)

Modeling the Control of TGF-β/Smad Nuclear Accumulation by the Hippo Pathway Effectors, Taz/Yap
por: Labibi, Bita, et al.
Publicado: (2020)

Dedifferentiation by adenovirus E1A due to inactivation of Hippo pathway effectors YAP and TAZ
por: Zemke, Nathan R., et al.
Publicado: (2019)

Physiological and pathological roles of the Hippo‐YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis
por: Nishina, Hiroshi
Publicado: (2022)

Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers
por: Howard, Alexander, et al.
Publicado: (2022)

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation
por: Venghateri, Jubina Balan, et al.
Publicado: (2023)

Hippo-YAP/TAZ signaling in osteogenesis and macrophage polarization: Therapeutic implications in bone defect repair
por: Wang, Haochen, et al.
Publicado: (2023)

The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment
por: Mokhtari, Reza Bayat, et al.
Publicado: (2023)

Establishment of a Novel Method for Spinal Discectomy Surgery in Elderly Rats in an In Vivo Spinal Fusion Model
por: Oswald, Katharina A. C., et al.
Publicado: (2021)

Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
por: Vici, Patrizia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t2flg4s9gnhh2p2lqlvbvi88ke