Adjuvant Activity of CpG-Oligonucleotide Administered Transcutaneously in Combination with Vaccination Using a Self-Dissolving Microneedle Patch in Mice

In this study, we investigated the mechanism of transcutaneous adjuvant activity of the CpG-oligonucleotide (K3) in mice. Transcutaneous immunization (TCI) with an ovalbumin-loaded self-dissolving microneedle patch (OVA-sdMN) and K3-loaded hydrophilic gel patch (HG) increased OVA-specific Th2- and T...

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Detalles Bibliográficos
Autores principales: Hirobe, Sachiko, Kawakita, Takuto, Yamasaki, Taki, Ito, Sayami, Tachibana, Masashi, Okada, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707324/
https://www.ncbi.nlm.nih.gov/pubmed/34960226
http://dx.doi.org/10.3390/vaccines9121480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707324/
https://www.ncbi.nlm.nih.gov/pubmed/34960226
http://dx.doi.org/10.3390/vaccines9121480

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