Hybrid Bis-Histidine Phenanthroline-Based Ligands to Lessen Aβ-Bound Cu ROS Production: An Illustration of Cu(I) Significance

We here report the synthesis of three new hybrid ligands built around the phenanthroline scaffold and encompassing two histidine-like moieties: phenHH, phenHGH and H’phenH’, where H correspond to histidine and H’ to histamine. These ligands were designed to capture Cu(I/II) from the amyloid-β peptid...

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Detalles Bibliográficos
Autores principales: Drommi, Marielle, Rulmont, Clément, Esmieu, Charlène, Hureau, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707446/
https://www.ncbi.nlm.nih.gov/pubmed/34946712
http://dx.doi.org/10.3390/molecules26247630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707446/
https://www.ncbi.nlm.nih.gov/pubmed/34946712
http://dx.doi.org/10.3390/molecules26247630

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