Primary Amine Nucleophilic Addition to Nitrilium Closo-Dodecaborate [B(12)H(11)NCCH(3)](−): A Simple and Effective Route to the New BNCT Drug Design

In the present work, a convenient and straightforward approach to the preparation of borylated amidines based on the closo-dodecaborate anion [B(12)H(11)NCCH(3)NHR]−, R=H, Alk, Ar was developed. This method has two stages. A nitrile derivative of the general form [B(12)H(11)NCCH(3)](−) was obtained,...

Descripción completa

Detalles Bibliográficos
Autores principales: Nelyubin, Alexey V., Selivanov, Nikita A., Bykov, Alexander Yu., Klyukin, Ilya N., Novikov, Alexander S., Zhdanov, Andrey P., Karpechenko, Natalia Yu., Grigoriev, Mikhail S., Zhizhin, Konstantin Yu., Kuznetsov, Nikolay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707455/
https://www.ncbi.nlm.nih.gov/pubmed/34948186
http://dx.doi.org/10.3390/ijms222413391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707455/
https://www.ncbi.nlm.nih.gov/pubmed/34948186
http://dx.doi.org/10.3390/ijms222413391

Ejemplares similares